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Meanwhile, mito-CD147 scFv significantly diminished the numbers of CTCs boosted by mitochondrial CD147 and its SOX2 levels in lactate-administered mice (Fig

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In summary, the nanomedicine system can intervene in inflammatory signal transduction through multiple strategies, including directly blocking the NF-B cascade reaction, positively activating anti-inflammatory pathways to negatively inhibit pro-inflammatory signals, and targeting apoptotic cells for local drug release