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This dual mechanism appears to produce even greater weight loss than single GLP-1 agonists alone

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In contrast, individuals with dyslipidaemia or hepatic steatosis might benefit more from treatment with a glucagon/T 3 conjugate where reductions in hepatic fat and circulating lipids are of primary importance

The most common side effects of Topiramate include: Tingling of the arms and legs (paresthesia) Not feeling hungry Nausea A change in the way foods taste Diarrhea Weight loss Nervousness Upper respiratory tract infection Speech problems Tiredness Dizziness Sleepiness/drowsiness Slow reactions Difficulty with memory Pain in the abdomen Fever Abnormal vision Decreased feeling or sensitivity, especially in the skin You are encouraged to report negative side effects of prescription drugs to the FDA