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In addition, polymer-based LYTACs couple PD-L1binding motifs with ASGPR ligands to drive liver tumorspecific lysosomal degradation of PD-L1 while sparing its expression on host immune cells

In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

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Increasing glutathione levels improves insulin resistance and fat-burning and have also been shown to improve insulin action and glucose metabolism