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The antioxidant activity is especially critical for the operation of glutathione peroxidase (GPx), an enzyme that catalyzes the reduction of peroxides using GSH as an electron donor, oxidizing it to its disulfide form, GSSG (glutathione disulfide)

Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals

However, this effect may be due to the large amount of cystine provided in the control conditions (208 M), as reduction of cystine levels in the medium did not impair growth but abolished intracellular cysteine and cystine levels (Extended Data Fig