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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer
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doi: 10.1002/14651858.CD005496.pub6 399 FanYLiuYShaoCJiangCWuLXiaoJet al
When the ligands bind to the LBD of AR, they translocate into the nucleus to form a homodimer, and the AR dimer interacts with its coregulatory proteins to recognize cognate DNA response elements located in the proximal or distal intragenic and intergenic regions of androgen target genes, thereby regulating gene expression (e.g., KLK3 , NKX3.1 , FKBP5 , TMPRSS2-ERG )
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