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The Journal of nutrition , 134 (3), 489-492

A peptide becoming more widely available does not mean it has been shown to be safe and effective through the FDA drug approval process, Khaldi says

GLP-1 medications, such as semaglutide and tirzepatide, mimic the action of the hormone GLP-1 in the body, helping to regulate appetite, blood sugar levels, and promote feelings of fullness after meals

If anything, people tend to become more functional, he says, because they can do more stuff and its easier to move around. But its not clear how previous clinical trial data translate to the wider population of people using weight loss medications in real life