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3 Synergistic pathogenic mechanisms of ferroptosis in DR 3.1 Vicious cycle mechanism of oxidative stress-BRB injury-ferroptosis Oxidative stress is defined as an imbalance between reactive oxygen species (ROS) and the endogenous antioxidant defense system, and the retinal tissue and cellular damage it mediates serves as a core pathological driver of diabetic retinopathy (DR) progression (151)

Branches: The canopy is umbrella-shaped, with extended branches that grow in an unorganized manner

In line with these findings, altered -amyloid deposition can inhibit aromatase, a key enzyme for converting androgens into estrogens (McCullough et al., 2003

Brightening eye cream can do a lot of the work, but a few simple habits can help reduce dark circles under the eyes Always wear SPF around the eye area (yes, even on cloudy days) because UV exposure is one of the biggest triggers for under-eye pigmentation