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To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed
Importantly, future studies on tirzepatide should specifically focus on sex differences, the role of reproductive status, and other major disease modifiers on treatment response [54, 55, 78, 79]
human evidence is limited, the combination is unstudied, and individual results vary
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