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Ghrelin receptor signaling, specifically in hypothalamic AgRP/NPY neurons, is a critical countermeasure to prevent hypoglycaemia (143)
While phentermine/topiramate extended-release resulted in consistent significant changes in BMI and waist circumference, only exenatide and dapagliflozin and exenatide alone resulted in significant improvements in insulin secretion as well as mean blood glucose over an oral glucose tolerance test
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