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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist approved for type 2 diabetes management and chronic weight management, requires specific storage conditions to maintain its stability and therapeutic efficacy
Patients with certain GLP1R variants may achieve therapeutic benefit at lower doses, while others require higher exposure for equivalent weight lossand mismatched dosing in either direction increases overdose or inefficacy risk
Clinical trials of Ozempic showed a decrease in haemoglobin A1C, which is a measure of blood sugar control, by 1% in 3 months [5]
Eur J Pain 2009;13(5):492-496
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