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Excessive weight gain associated with sulfonylureas and insulin treatment is not benign and results in worsening of well-known cardiovascular risk factors, potentially contributing to the increased macro-vascular risk

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Research Applications Appetite and feeding behavior: The established primary application characterizing NPY/AgRP-mediated orexigenic signaling in preclinical models using the compound most reliably activating those circuits Energy homeostasis: Ghrelins role in energy balance, adipogenesis, and metabolic adaptation during caloric restriction