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Utilizing PHTPP, a selective ESR2 antagonist, the authors demonstrate that the therapeutic benefits of exercise are largely reliant on the ESR2-mediated signaling system, therefore providing novel insights into the processes governing exercise treatment for KOA [110]

a naturally occurring tripeptide-copper chelate found in human plasma, saliva, and urine

Less muscle means a slower metabolism, reduced insulin sensitivity, and shifts in body composition and strength that heighten the risk for weight gain, fatigue, and bone loss over time