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The 1990s: Expanding Tissue Research and Mechanism Work The 1990s saw the research base for GHK-Cu expand considerably beyond the original liver and wound contexts

thus, resistant peptic ulcers equal to resistant chronic skin ulcers, both unable to heal (Skorjanec et al., 2009)

While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig