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[1] Retatrutide: What the Evidence Actually Shows Retatrutides pivotal obesity dataset is a Phase 2, double-blind, randomised, placebo-controlled trial in adults with obesity (or overweight plus a weight-related condition), testing once-weekly doses up to 12 mg over 48 weeks

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Head-to-head, Mounjaro consistently produces greater weight loss than Wegovy across all dose levels in clinical trial data

This also raises the important consideration of whether it is ethical to compare an intervention with a placebo, in circumstances where the intervention has such broadly proven alternative long-term health benefits