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This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult

Additionally, GLP-1 RAs inhibit appetite and the brain's reward mechanisms, effectively maintaining body weight reductions for at least 4 to 5 years

If the telehealth partner bundles medication and clinical oversight, conversion tends to be higher and patient retention improves

Given the benefits of rapid diffusion, favorable blood-brain barrier permeability and versatile administration routes, these small molecule compounds will be one of the important candidates of GLP-1RA