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Glycemic and Cardiovascular Outcomes Research Among the most cited findings is the SUSTAIN-6 trial, a large randomized placebo-controlled study in patients with type 2 diabetes, which reported that semaglutide significantly reduced the rate of major adverse cardiovascular events alongside improvements in glycemic measures establishing the GLP-1R agonist class as cardiometabolically active beyond glucose lowering 2

It can, especially during the early stages of treatment

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It was designed specifically to evaluate retatrutide in the broadest obesity population adults without diabetes and to serve as the primary evidence base for FDA approval