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Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application
Due to the different levels of enzyme defect with various mutations and the different genes there is wide variability in the severity of the clinical symptoms
In addition, prolonged antigen exposure and continued stimulation of CD8 T cells leads to CD8 T cell exhaustion, which represents a significant challenge to the effectiveness of the immune response against chronic viral infections and tumor development (135, 136, 223)
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