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In lipopolysaccharide (LPS) stimulated macrophages, capsaicin suppresses activation of NF-B and MAPK pathways, as shown by reduced phosphorylation of p38, p65, and extracellular signal regulated kinase (ERK), leading to decreased production of nitric oxide (NO), TNF-, IL-6, and cyclooxygenase-2 (COX-2) (78, 79)
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