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Despite these promising findings, few studies have investigated the potential impact of these diets on anticancer treatment of gastrointestinal cancers, and further studies are necessary to better understand the biological mechanisms and to evaluate the safety and effectiveness of these strategies in broader clinical settings
Haynes et al , 2004)
High-fat foods may worsen gastrointestinal symptoms, particularly during dose escalation phases
Interestingly, endothelial nitric oxide synthase (eNOS) can also reduce DOX to its semiquinone form, enhancing superoxide formation and decreasing nitric oxide production
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