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Heart rate increases slightly with both medications

Specifically: Whether 2.5 mg per week sustains weight loss as effectively as 5 mg over 72 weeks remains unstudied Whether weight regain happens faster at lower maintenance doses if treatment is paused remains unknown Whether the cardiovascular and metabolic benefits seen at 5 mg and above apply at lower doses has not been tested Whether longer titration schedules produce different long-term outcomes than the standard 4-weeks-per-step regimen has limited data The body of evidence underpinning tirzepatide's approval is built on the 5/10/15 mg structure with a 2.5 mg starter step