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Accompanying the increase in use of these drugs has been a surge in individuals seeking guidance regarding their side effects, as well as accidental overdoses

Rather than jumping to high therapeutic doses, microdose approaches introduce semaglutide or tirzepatide at lower amounts, titrating more gradually to minimize nausea, vomiting, and gastrointestinal upset

Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

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