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Interaction Neuronal cells, myoblast, T cells, B cells, NK cells Ligand/Receptor IGF-I receptor, Insulin receptor isoform A, and IGF-II receptor (M-6-P-R) Bioactivity Human LR3 IGF-1 induces the proliferation of MCF-7 human epithelial cells

Therefore, its use should be avoided in these populations

It turns out the GLP-1 mechanism is at play too: Berberine GLP-1 agonist The research community has known since 2009 -- and perhaps longer -- that berberine is a GLP-1 agonist, promoting GLP-1 amide secretion