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It mimics a natural gut hormone, acting on appetite centres in the brain to increase fullness and reduce hunger, and is used together with a reduced-calorie diet and increased physical activity in adults
Summary: GLP-1 receptor agonists commonly cause acid reflux and heartburn by delaying gastric emptying, which increases stomach pressure and promotes reflux of stomach contents into the oesophagus
The Gastric-Emptying Connection A 2022 scintigraphy study published in Diabetes Care confirmed that tirzepatide at 15 mg reduces the gastric emptying rate of solids by roughly 26 percent compared to placebo [1]
More recently developed cytofluorometric assays detect the quenching of glutaraldehyde-induced autofluorescence by formazan using flow cytometry [43, 44]
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