That we may need higher level interventions to really turn that around so that those diet and lifestyle efforts can have a greater impact, which is what you said at the top of this, but I want to remind people of that because I think when we have these conversations about these medications, there's, it falls into two camps, like the people who are like, give it to everyone, it saves that, like all of these things, all these wonderful things
Exogenous melatonin has acute sleepiness-inducing and temperature-lowering effects during 'biological daytime', and when suitably timed (it is most effective around dusk and dawn), it will shift the phase of the human circadian clock (sleep, endogenous melatonin, core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times
GLP-1 RAs mimic the action of glucagon-like peptide-1 to suppress appetite and delay gastric emptying
Semaglutide is not a vitamin you skip for a while and pick back up without consequence