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Despite that low penetrance, partial deficiency of CCT in B cells resulted in decreased peritoneal and splenic B cell numbers, inducing a compromised proliferation, especially in the periphery, decreasing serum IgG concentration, and increasing the incidence of IgM-secreting cells (107)

Data were low-pass filtered at 4 kHz and acquired at 10 kHz with an Axon Multiclamp 700B amplifier and an Axon Digidata 1550 Data Acquisition System under the control of Clampex 10.5 (Molecular Devices)