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While numerous proof-of-concept candidate molecules have been disclosed (3443), the only approved example of multi-receptor agonism for obesity and T2D is the dual GLP-1R/GIPR co-agonist tirzepatide (marketed as Mounjaro and Zepbound ) (34, 44)

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Lo studio REDEFINE 1 ha arruolato 3.417 adulti senza diabete con indice di massa corporea (BMI) di almeno 30 kg/m, o di almeno 27 kg/m in presenza di comorbidit correlate allobesit come ipertensione o dislipidemia

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The association between lymphedema and autoimmunity: a large case control study

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