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It is worth noting that a trial of the anti-diabetic agent pioglitazone (PPAR agonist) in ALS with the rationale of attenuating inflammation, failed to show any benefit 9
Key findings at the highest dose (12mg weekly): Up to 24% mean body weight reduction over 48 weeks Significant reductions in fasting glucose and insulin resistance markers Meaningful reductions in liver fat content, relevant for participants with metabolic-associated fatty liver disease Once-weekly subcutaneous dosing was generally well-tolerated For context, semaglutide at its approved dose achieves approximately 1517% body weight reduction over 68 weeks
The role of NPY in appetite control can be demonstrated by central administration of NPY which results in a markedly increased desire for food intake
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