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In overweight individuals, GLP-1 agonists make weight loss easier by diminishing appetite and food intake

Despite these findings, to our knowledge, there are no large population-based studies that have investigated the incidence of new-onset major cardiovascular events or clinically significant portal hypertension events in patients with MASLD who are receiving treatment with GLP-1 agonists for any indication

it is unknown whether Ozempic causes these in humans, but it is contraindicated in patients with a medical history of medullary thyroid carcinoma (Ozempic prescribing information)