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Collectively, these data suggest that the Glp1r -independent effects of GLP-1(736) are exerted following its degradation to GLP-1(936) and is mediated by activation of G i/o
Glucagon-like-peptide-1 receptor agonists (GLP-1s), including medications like Ozempic and Zepbound, have transformed weight management and treatment of chronic disease
First, GLP-1s interact with specific receptors in the brain that are involved in regulating hunger and satiety cues
Such data would be important for predicting the state of neuroendocrine aging and theoretically as interventions become available, be valuable in knowing when to begin therapy
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