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The transgenic overexpression of HGF in the nervous system attenuates spinal motoneuronal death and axonal degeneration, delays onset of the disease, and prolongs the lifespan of SOD1-G93A mice (Sun et al., 2002)
J Orthop Surg Res 18 , 769 (2023)
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Based on these pre-clinical findings, a lead candidate, SAR425899 with similar receptor potencies was taken forward in Phase 1 and Phase 2 trials (see below)
![PDF] Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models](https://figures.semanticscholar.org/d83a64f6b7193358c31030487761fc19c80dd33c/3-Figure1-1.png)
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