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Importantly, increasing the endogenous production of GLP-1 by different mechanisms or by increasing the number of intestinal L-cells that tend to produce this hormone may be another effective therapeutic approach to managing T2DM

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Increase tirzepatide to therapeutic dose (12.515mg weekly), ensure 5-amino-1MQ is dosed consistently at 100mg daily, and implement structured dietary intake with adequate protein (1.62.2g/kg) to support the catabolic shift both compounds induce