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The vast majority, if they stick with it, will tolerate it just fine and only a small minority, in my experience, have to stop completely. Hurtado Andrade added that up to one-third of patients may have some side effects when they start a GLP-1 agent that may require dosage adjustments to find the sweet spot. But another aspect thats important for patients being prescribed GLP-1 agonists to understand, she added, is that using them in the real world may look much different than in clinical trials

Phase Moderate range Daily dose 40-80 mcg/day Frequency Once daily Notes Diminishing returns commonly reported above ~50-60 mcg/day

Contraindicated in pregnancy and breastfeeding due to absence of safety data