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The pharmacokinetics and pharmacodynamics of SGLT2 inhibitors for type 2 diabetes mellitus: the latest developments

The SELECT trial followed more than 17,000 adults with established cardiovascular disease and a BMI of 27 or higher, none of whom had diabetes

The result is a compound that reduces appetite through GLP-1, enhances insulin sensitivity through GIP, and actively burns stored fat through glucagon receptor engagement

Some small studies, they note, have suggested that exercise can help improve VO2max for patients taking GLP-1 drugs, but these had poor controls and larger, well-designed studies are needed to bear that out