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It is also important to note that LAC levels are decreased in obese subjects [63], emphasizing the need for future studies aimed at exploring a possible link between LAC metabolism and obesity in subjects with MDD

Steph put it in a way that hits home: If we truly viewed obesity as a chronic disease then bariatric surgery and GLP-1 medications are treatments, not tests you pass or fail. Steph Wagner Obesity is a chronic disease, and chronic disease needs lifelong treatment

it must involve nurturing the internal environment of the gut

Basic concepts in population modeling, simulation, and model-based drug development: part 3-introduction to pharmacodynamic modeling methods