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Patients with pacemakers who also take digoxin, a cardiac glycoside used for certain arrhythmias, should inform their prescribing physician because rapid weight loss can affect drug levels in the bloodstream
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Clinical Efficacy Data: Head-to-Head Comparison Framework Weight loss outcomes differ meaningfully across these medications in published trials
Similarly, the SURMOUNT-4 trial showed substantial weight regain following tirzepatide discontinuation
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