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Furthermore, in other disease models (such as A-induced nerve cell damage), highly expressed or activated VDAC1 has been clearly involved in ferroptosis, exacerbating cell death by inhibiting anti-ferroptosis pathways (such as GPX4, AMPK/mTOR, Wnt/-catenin) (149)
Site possibility threshold for peptide-to-spectrum matching (PSM) was set to minimum 75 for PTM site localization
47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG
Gemfibrozil alleviates cognitive impairment by inhibiting ferroptosis of astrocytes via restoring the iron metabolism and promoting antioxidant capacity in type 2 diabetes
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