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However, 3-KO mice failed to show any significant changes in body weight following treatment with AOD9604 or hGH
Safety data from trials In a paper summarizing 6 randomized, double-blind, placebo-controlled human trials, AOD 9604 did not significantly affect IGF-1 levels, did not impair glucose tolerance, and no serious adverse events (SAEs) were attributed to AOD 9604
Key finding: AOD 9604 reduced serum leptin by 56%, improved hypothalamic STAT3 phosphorylation, and restored leptin-induced POMC expression
However, clinical evidence tells a more nuanced story
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