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Eli Lilly and Company, the manufacturer of Zepbound, advises patients to contact their healthcare professional if they experience severe stomach problems. Seek medical advice if your Zepbound sulfur burps are accompanied by: severe or persistent vomiting or diarrhea intense pain in the upper stomach area that may spread to your back (a possible sign of pancreatitis) signs and symptoms of dehydration, such as dark urine or extreme thirst fever or yellowing of the skin or eyes (jaundice) Sulfur burps are a smelly but harmless side effect of Zepbound caused by how the medication slows down digestion

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Semaglutide targets GLP-1 receptors, while tirzepatide targets both GLP-1 and GIP receptors, which may enhance its effects on appetite and metabolism