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The Food and Drug Administration (FDA) warns that severe dehydration from GLP-1 drugs may raise the risk of kidney injury and damage
doi: 10.1038/nature09922 70 XiaY.LiQ.ZhongW.DongJ.WangZ.WangC
If standard doses are not tolerated, clinically appropriate alternatives might include slower titration (still within SmPC guidelines), switching to a different GLP-1 receptor agonist, considering other medication classes, enhancing diet/lifestyle support, or specialist review
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