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placebo Notable finding : PT-141 demonstrated efficacy in a subset of men who had previously failed sildenafil therapy, suggesting its central mechanism could bypass the peripheral pathway deficits underlying PDE5 inhibitor non-response [18] A subsequent study by Safarinejad (2008) evaluated subcutaneous PT-141 in 75 men with ED who were non-responsive to sildenafil, confirming that 32% of sildenafil non-responders achieved successful intercourse with PT-141 treatment [19]

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