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As anticipated, the ANOVA significant DIA sites were mainly upregulated in HeLa cells after 10 min EGF stimulation with an average log2 fold-change of 1.0 and belonging to the clusters B, C, and D of intermediate stimulators, late stimulators, and terminal effectors defined in the HeLa dataset 2

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By activating GLP-1 receptors, retatrutide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, and reduces appetite