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Heinla, K
What to Do If You Have Trouble Even with all these tips, you might still have a tummy problem
In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100300 fold, whereas for exendin-4, this has no effect, albeit, for both peptides, these residues are required for GLP-1R-mediated cAMP production 22,23,24,25
For nausea and general digestive discomfort, strains such as Lactobacillus rhamnosus GG have shown benefits in various gastrointestinal conditions, though specific data in the context of GLP-1 medications remain limited
