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Results were presented at the 2025 EASD meeting and published in The New England Journal of Medicine
From a therapeutic benefit standpoint, impaired GLP-1 secretion mediated by blood glucose has been observed in MASLD patients
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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)
