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Results revealed a reduction in hepatic lipid accumulation and oxidative stress, hepatic fibrosis via modulation of -smooth muscle actin (SMA), peroxisome-activated receptor gamma (PPAR), and nuclear factor kappa B (Nf-B) expression (87)
It's working heroically to keep everything running despite the oxygen deficit
These pathways have simultaneously developed for organ-specific adaptation to meet the physiological demands specific to each organ, sensing glucose in pancreatic -cells for insulin secretion, and sensing various nutrients like amino acids, fatty acids, and glucose for GLP-1 secretion in intestinal L-cells 32
Within the pancreas, GIP and GLP act collectively to promote -cell proliferation and inhibit apoptosis and also play critical roles in various biological processes in tissues and organs that express GIP receptor and GLP-1 receptor
