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Studies of SEMA in metabolic liver disease have shown improvement in steatohepatitis with daily administration, but the results have been less satisfactory regarding the improvement of fibrosis at stages F2F3 or F4,30 or with a weekly dose of 2.4 mg over 72 weeks.31 The results of the new phase III ESSENCE trial, evaluating SEMA 2.4 mg over 240 weeks, are highly anticipated
The medication must remain refrigerated, so a cooler with ice packs is necessary for trips longer than a few hours
By reducing estrogen, it helps maintain hormonal balance and mitigate side effects like gynecomastia
However, these side effects are often temporary and manageable
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