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General procedure for experimental methods NMR analysis The conversion of GSH into GSSG was monitored by NMR (Bruker Avance 400)

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As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders