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Cold-turkey discontinuation may set up regain because four forces converge: appetite returns as the drug washes out, lean mass lost during the deficit is already gone, retatrutides glucagon-arm metabolic lift fades fast, and hunger-hormone defenses persist for about 12 months after major weight loss
The longer answer requires understanding specific safety considerations that thyroid patients cannot afford to ignore
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2A and B and 3 B, C)
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