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Black Box Warning (May 2017): RISK OF TOE / LOWER LIMB AMPUTATION Two clinical trials (CANVAS & CANVAS-R) have indicated an increased risk increase in lower limb amputations (mostly affecting the toes) in patients taking canagliflozin
TRIUMPH-6 focuses on obstructive sleep apnea with concomitant obesity, targeting the same comorbidity where tirzepatide has already secured a label expansion via SURMOUNT-OSA
It wasnt until 2009 that researchers, through serendipity, realized that besides improving blood sugar levels, GLP-1s had a significant effect on weight loss
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