heavy period on semaglutide and metformin improve menstrual cyclicity in overweight/obese women with polycystic ovary syndrome: a randomized trial Woman With PCOS Takes Semaglutide:

[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance

This is the period where the medication reaches full therapeutic dose (12mg by week 13) and genuine fat oxidation dominates the weight loss pattern

Geisinger has walked this tightrope in the past, but as economic pressures mount, I fear doctors will find the two sets of incentives conflicting and difficult to navigate

If your cat is already lean and thriving, it may not add much