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Nonetheless, considerable concerns arise regarding the specificity of NERNST due to its dependence on a redox-sensitive green fluorescent protein (roGFP2) reporter, which is known to efficiently equilibrate with the glutathione redox couple in vivo 19,20,21,22

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However, this does not eliminate long-term hepatotoxic risk alcohol-related liver disease develops through cumulative damage from chronic consumption, and no supplement negates the dose-response relationship between alcohol intake and cirrhosis risk